store at low temperature
Clervonafusp alfa (VAL-1221) is a fusion protein designed to target both cytosolic and lysosomal glycogen, thereby addressing the underlying mechanisms of Pompe disease. This compound integrates the Fab segment of a cell-penetrating antibody with recombinant human acid alpha-glucosidase (rhGAA). The antibody's Fab portion exploits the nucleoside transporter ENT-2 for cytosolic entry, while the rhGAA component accesses lysosomes through mannose-6-phosphate receptors (M6PRs). This dual-targeting approach positions Clervonafusp alfa as a potential therapeutic research candidate for late-onset Pompe disease [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | Clervonafusp alfa (VAL-1221) is a fusion protein designed to target both cytosolic and lysosomal glycogen, thereby addressing the underlying mechanisms of Pompe disease. This compound integrates the Fab segment of a cell-penetrating antibody with recombinant human acid alpha-glucosidase (rhGAA). The antibody's Fab portion exploits the nucleoside transporter ENT-2 for cytosolic entry, while the rhGAA component accesses lysosomes through mannose-6-phosphate receptors (M6PRs). This dual-targeting approach positions Clervonafusp alfa as a potential therapeutic research candidate for late-onset Pompe disease [1]. |
Molecular Weight | N/A |
CAS No. | 2145123-44-8 |
store at low temperature
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Clervonafusp alfa 2145123-44-8 inhibitor inhibit