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Ubiquitin Isopeptidase Inhibitor I, G5

🥰Excellent
Catalog No. T17192Cas No. 108477-18-5
Alias NSC144303

Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).

Ubiquitin Isopeptidase Inhibitor I, G5

Ubiquitin Isopeptidase Inhibitor I, G5

🥰Excellent
Purity: 96.56%
Catalog No. T17192Alias NSC144303Cas No. 108477-18-5
Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).
Pack SizePriceAvailabilityQuantity
5 mg$74In Stock
10 mg$128In Stock
25 mg$217In Stock
50 mg$319In Stock
100 mg$478In Stock
500 mg$1,090In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:96.56%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).
Targets&IC50
E1A/C9DN cells:1.6 μM, E1A cells:1.76 μM
In vitro
Ubiquitin Isopeptidase Inhibitor I, G5 is a more effective apoptosis inducer, with IC50 values of 1.76 μmol/L and 1.6 μmol/L in E1A and E1A/C9DN cells, respectively[1].
SynonymsNSC144303
Chemical Properties
Molecular Weight414.39
FormulaC19H14N2O7S
Cas No.108477-18-5
Smiles[O-][N+](=O)c1ccc(\C=C2/CS(=O)(=O)C\C(=C/c3ccc(cc3)[N+]([O-])=O)C2=O)cc1
Relative Density.1.541 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (48.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4132 mL12.0659 mL24.1319 mL120.6593 mL
5 mM0.4826 mL2.4132 mL4.8264 mL24.1319 mL
10 mM0.2413 mL1.2066 mL2.4132 mL12.0659 mL
20 mM0.1207 mL0.6033 mL1.2066 mL6.0330 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ubiquitin Isopeptidase Inhibitor I, G-5Ubiquitin Isopeptidase Inhibitor I, G5NSC-144303NSC 144303E1A/C9DN cellsE1A cellsApoptosis
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