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GDC0575 monohydrochloride

🥰Excellent
Catalog No. T27407Cas No. 1196504-54-7
Alias GDC-0575, GDC0575, GDC 0575, ARRY-575, ARRY575

GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.

GDC0575 monohydrochloride
Other Forms of GDC0575 monohydrochloride:

GDC0575 monohydrochloride

🥰Excellent
Purity: 97.85%
Catalog No. T27407Alias GDC-0575, GDC0575, GDC 0575, ARRY-575, ARRY575Cas No. 1196504-54-7
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$38In StockIn Stock
2 mg$53In StockIn Stock
5 mg$77In StockIn Stock
10 mg$110In StockIn Stock
25 mg$197In StockIn Stock
50 mg$283In StockIn Stock
100 mg$396In StockIn Stock
200 mg$577In StockIn Stock
1 mL x 10 mM (in DMSO)$89In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.85%
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Product Introduction

Bioactivity
Description
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
Targets&IC50
Chk1:1.2 nM
SynonymsGDC-0575, GDC0575, GDC 0575, ARRY-575, ARRY575
Chemical Properties
Molecular Weight414.73
FormulaC16H21BrClN5O
Cas No.1196504-54-7
SmilesO=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (144.67 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4112 mL12.0560 mL24.1121 mL120.5604 mL
5 mM0.4822 mL2.4112 mL4.8224 mL24.1121 mL
10 mM0.2411 mL1.2056 mL2.4112 mL12.0560 mL
20 mM0.1206 mL0.6028 mL1.2056 mL6.0280 mL
50 mM0.0482 mL0.2411 mL0.4822 mL2.4112 mL
100 mM0.0241 mL0.1206 mL0.2411 mL1.2056 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

GDC-0575 MonohydrochlorideGDC-0575 monohydrochlorideGDC0575 MonohydrochlorideGDC0575 monohydrochlorideGDC 0575 MonohydrochlorideChk1ARRY 575
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