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IT1t dihydrochloride

Name: IT1t dihydrochloride
Brand: TargetMol
SKU: T11693L
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11693LCas No. 1092776-63-0

IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.

IT1t dihydrochloride

🥰Excellent

Purity: 99.91%

Catalog No. T11693LCas No. 1092776-63-0

IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$322	In Stock	In Stock
100 mg	$467	In Stock	In Stock
200 mg	$648	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
Targets&IC50	HIV-1 (X4):14.2 nM (in MT-4 cells), CXCL12-CXCR4:2.1 nM, HIV-1 (X4):19 nM (in PBMCs)
In vitro	AMD11070 shows antagonistic activity as it dose-dependently inhibits the CXCL12-induced intracellular calcium flux This calcium flux is inhibited by IT1t dihydrochloride with an IC50 of 23.1[1].
In vivo	IT1t dihydrochloride reduces the formation of early metastases of TNBC in a zebrafish xenograft model. After CXCR4 silencing, tumor cell invasion at metastatic sites was effectively reduced [3].

Chemical Properties

Molecular Weight	479.57
Formula	C₂₁H₃₆Cl₂N₄S₂
Cas No.	1092776-63-0
Smiles	Cl.Cl.CC1(C)CN2C(CS\C(NC3CCCCC3)=N/C3CCCCC3)=CSC2=N1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27 mg/mL (56.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0852 mL	10.4260 mL	20.8520 mL	104.2601 mL
5 mM	0.4170 mL	2.0852 mL	4.1704 mL	20.8520 mL
10 mM	0.2085 mL	1.0426 mL	2.0852 mL	10.4260 mL
20 mM	0.1043 mL	0.5213 mL	1.0426 mL	5.2130 mL
50 mM	0.0417 mL	0.2085 mL	0.4170 mL	2.0852 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc