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Multitarget AD inhibitor-1

Catalog No. T39678 CAS 2205015-77-4

Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, disease-modifying treatment of Alzheimer's disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Multitarget AD inhibitor-1 Chemical Structure

Multitarget AD inhibitor-1, CAS 2205015-77-4

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Biological Description

Chemical Properties

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Description

In vitro

Multitarget Alzheimer's Disease (AD) inhibitor-1 (compound 10) selectively inhibits both equine serum butyrylcholinesterase (eqBuChE) and human butyrylcholinesterase (hBuChE) over acetylcholinesterase from electric eel (eeAChE), achieving a 21.78% inhibition at a concentration of 10 μM[1]. Additionally, at the same concentration, this compound impedes the aggregation of full-length tau protein by 44.4%[1], showcasing its potential as a multifunctional therapeutic agent for AD.

Molecular Weight	430.636
Formula	C29H38N2O
CAS No.	2205015-77-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dawid Panek, et al. Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents. ACS Chem Neurosci. 2018 May 16;9(5):1074-1094.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Multitarget AD inhibitor-1 2205015-77-4 Multitarget AD inhibitor 1 Multitarget AD inhibitor1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.