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ML277

Name: ML277
Brand: TargetMol
SKU: T3303
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3303Cas No. 1401242-74-7

Alias ML-277, CID-53347902

ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

ML277

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Purity: 99.35%

Catalog No. T3303Alias ML-277, CID-53347902Cas No. 1401242-74-7

ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$71	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$322	In Stock	In Stock
100 mg	$483	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.35%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).
Targets&IC50	K+ channel:270 nM
In vitro	ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. IC50 value: 270 nM (EC50) [1] Target: K(v)7.1 activator ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel[1].
Synonyms	ML-277, CID-53347902

Chemical Properties

Molecular Weight	471.59
Formula	C₂₃H₂₅N₃O₄S₂
Cas No.	1401242-74-7
Smiles	COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1
Relative Density.	1.341 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (127.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1205 mL	10.6024 mL	21.2049 mL	106.0243 mL
5 mM	0.4241 mL	2.1205 mL	4.2410 mL	21.2049 mL
10 mM	0.2120 mL	1.0602 mL	2.1205 mL	10.6024 mL
20 mM	0.1060 mL	0.5301 mL	1.0602 mL	5.3012 mL
50 mM	0.0424 mL	0.2120 mL	0.4241 mL	2.1205 mL
100 mM	0.0212 mL	0.1060 mL	0.2120 mL	1.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc