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JNJ-37822681

Name: JNJ-37822681
Brand: TargetMol
SKU: T27677
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27677Cas No. 935776-74-2

Alias JNJ37822681, JNJ 37822681

JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.

JNJ-37822681

🥰Excellent

Purity: 99.84%

Catalog No. T27677Alias JNJ37822681, JNJ 37822681Cas No. 935776-74-2

JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
2 mg	$126	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$487	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$212	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.84%

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COA LCMS

Product Introduction

Bioactivity

Description	JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.
Targets&IC50	D2:0.39 mg/kg(ED50)
In vivo	JNJ-37822681 occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].
Synonyms	JNJ37822681, JNJ 37822681

Chemical Properties

Molecular Weight	372.34
Formula	C₁₇H₁₇F₅N₄
Cas No.	935776-74-2
Smiles	C(C1=CC(F)=C(F)C=C1)N2CCC(NC3=CC=C(C(F)(F)F)N=N3)CC2
Relative Density.	1.383 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (147.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6857 mL	13.4286 mL	26.8572 mL	134.2859 mL
5 mM	0.5371 mL	2.6857 mL	5.3714 mL	26.8572 mL
10 mM	0.2686 mL	1.3429 mL	2.6857 mL	13.4286 mL
20 mM	0.1343 mL	0.6714 mL	1.3429 mL	6.7143 mL
50 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6857 mL
100 mM	0.0269 mL	0.1343 mL	0.2686 mL	1.3429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc