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CTX-0124143

Name: CTX-0124143
Brand: TargetMol
SKU: T71832
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71832Cas No. 423731-64-0

CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.

CTX-0124143

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Purity: 98.24%

Catalog No. T71832Cas No. 423731-64-0

CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	-	In Stock
5 mg	$74	-	In Stock
10 mg	$119	-	In Stock
25 mg	$221	-	In Stock
50 mg	$343	-	In Stock
100 mg	$453	-	In Stock
200 mg	$611	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.24%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

CTX-0124143 AI Summary

CTX-0124143 exhibits bioactivity as an inhibitor of the N-terminal NusA-fused His6-tagged human KAT6A enzyme. It inhibits the enzyme's activity by targeting acetyl coenzyme A and the N-terminal histone H4 peptide as substrates, showing IC50 values of 12000.0 nM and 490.0 nM, respectively, under described assay conditions. Additionally, using Alpha screen technology, an IC50 value of 1000.0 nM was observed after a 60-minute incubation period. The compound also inhibits KAT7 and KAT5 with IC50 values greater than 200,000.0 nM and demonstrates a 49.0% reduction in H3K14ac and H3K9ac acetylation at a 10 µM concentration compared to controls, highlighting its potential in modulating acetylation levels..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

CTX-0124143 is a histone acetyltransferase inhibitor with an IC50 value of 1.0 μM for KAT6A.CTX-0124143 can be used to study cellular senescence.

Chemical Properties

Molecular Weight	344.36
Formula	C₁₇H₁₃FN₂O₃S
Cas No.	423731-64-0
Smiles	FC1=C(C=CC=C1)C(=O)NNS(=O)(=O)C1=CC2=CC=CC=C2C=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (159.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9039 mL	14.5197 mL	29.0394 mL	145.1969 mL
5 mM	0.5808 mL	2.9039 mL	5.8079 mL	29.0394 mL
10 mM	0.2904 mL	1.4520 mL	2.9039 mL	14.5197 mL
20 mM	0.1452 mL	0.7260 mL	1.4520 mL	7.2598 mL
50 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4520 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc