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2-Arachidonoylglycerol

Name: 2-Arachidonoylglycerol
Brand: TargetMol
SKU: T14011
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14011Cas No. 53847-30-6

2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.

2-Arachidonoylglycerol

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Catalog No. T14011Cas No. 53847-30-6

2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg (26.4 mM * 100 μL in Acetonitrile)	$118	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95% (as a 9:1 mixture of the 2-AG and 1-AG)

Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses.
Targets&IC50	CB1:0.8 μM
In vitro	2-Arachidonylglycerol (2-AG), a cannabinoid ligand obtained from intestinal tissue, functions as a full agonist in activating neuronal cannabinoid receptors. It impedes the development of long-term potentiation at CA3-CA1 synapses and, by binding to cannabinoid receptors, produces effects characteristic of cannabinoid drugs[1].

Chemical Properties

Molecular Weight	378.55
Formula	C₂₃H₃₈O₄
Cas No.	53847-30-6
Smiles	O(C(CO)CO)C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O
Relative Density.	0.992 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (26.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6417 mL	13.2083 mL	26.4166 mL	132.0829 mL
5 mM	0.5283 mL	2.6417 mL	5.2833 mL	26.4166 mL
10 mM	0.2642 mL	1.3208 mL	2.6417 mL	13.2083 mL
20 mM	0.1321 mL	0.6604 mL	1.3208 mL	6.6041 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc