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B2

Name: B2
Brand: TargetMol
SKU: T22595
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22595Cas No. 115687-05-3

Alias Linazolamide intermediate B impurity 2, CPNQ, 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease

B2

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Purity: 99.66%

Catalog No. T22595Alias Linazolamide intermediate B impurity 2, CPNQ, 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinolineCas No. 115687-05-3

B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$41	In Stock	In Stock
5 mg	$65	In Stock	In Stock
10 mg	$103	In Stock	In Stock
25 mg	$176	In Stock	In Stock
50 mg	$251	In Stock	In Stock
100 mg	$363	In Stock	In Stock
200 mg	$483	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.66%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

B2 AI Summary

B2 shows moderate inhibitory activity against SIRT2 with an IC50 value of 35,000.0 nM, and is less effective against SIRT1 and SIRT3, with IC50 values greater than 50,000.0 nM for both. This compound also has diverse bioactivities, including inhibition of mitochondrial division, activation of the Rab9 promoter, inhibition of the mTORC1 signaling pathway, induction of genotoxicity, and inhibition of Nrf2. Additionally, B2 inhibits interactions with methylated histone tails, histone lysine methyltransferase G9a, T. brucei phosphofructokinase, ELG1-dependent DNA repair, and human Flap endonuclease 1. It also inhibits binding or entry into cells by Lassa Virus and Marburg Virus, serves as a substrate for mammalian selenoprotein thioredoxin reductase 1, and enhances Arylsulfatase A activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease
Synonyms	Linazolamide intermediate B impurity 2, CPNQ, 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Chemical Properties

Molecular Weight	396.83
Formula	C₂₀H₁₇ClN₄O₃
Cas No.	115687-05-3
Smiles	[O-][N+](=O)c1ccc(N2CCN(CC2)C(=O)c2ccc(Cl)cc2)c2cccnc12
Relative Density.	1.412 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 2 mg/mL (5.04 mM), Sonication is recommended.

DMSO: 50 mg/mL (126 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5200 mL	12.5999 mL	25.1997 mL	125.9985 mL
5 mM	0.5040 mL	2.5200 mL	5.0399 mL	25.1997 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2520 mL	1.2600 mL	2.5200 mL	12.5999 mL
20 mM	0.1260 mL	0.6300 mL	1.2600 mL	6.2999 mL
50 mM	0.0504 mL	0.2520 mL	0.5040 mL	2.5200 mL
100 mM	0.0252 mL	0.1260 mL	0.2520 mL	1.2600 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc