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Acacetin
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Catalog No. T3981Cas No. 480-44-4
Alias Linarigenin, 5,7-Dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, exhibiting antinociceptive, anti-inflammatory, and antioxidant activities in different research models.
Acacetin
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Purity: 98.81%
Catalog No. T3981Alias Linarigenin, 5,7-Dihydroxy-4'-methoxyflavone, 4'-MethoxyapigeninCas No. 480-44-4
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, exhibiting antinociceptive, anti-inflammatory, and antioxidant activities in different research models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $30 | In Stock | In Stock | |
| 10 mg | $44 | In Stock | In Stock | |
| 25 mg | $76 | In Stock | In Stock | |
| 50 mg | $115 | In Stock | In Stock | |
| 100 mg | $173 | - | In Stock | |
| 500 mg | $436 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.81%
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Product Introduction
Acacetin AI Summary
Acacetin is a multifaceted bioactive molecule exhibiting a broad spectrum of biological activities. It displays significant antioxidant properties, as evidenced by its ability to inhibit superoxide production in various assays, including xanthine/xanthine oxidase and in BALB/c mouse bone marrow cells, with respective IC25 values of 16.3 µM and 1180.0 µM. It also shows substantial inhibitory effects on cytochrome P450 enzymes, particularly CYP1B1 (IC50 of 7.0 nM), and other CYP1 enzymes (CYP1A1 and CYP1A2 with IC50s of 80.0 nM).
Additionally, Acacetin demonstrates considerable bioactivity against mitochondrial enzymes, inhibiting NADH oxidase, succinoxidase, and ATPase activities in mitochondrial assays. It exhibits chemopreventive action by inhibiting the metabolism of benzo[a]pyrene in Chinese hamster embryonic cells and shows cytotoxicity against various cancer cell lines, with an IC50 of 0.4 µg/mL in an SRB assay.
Moreover, Acacetin acts as an agonist for the glucocorticoid receptor, androgen receptor, PPARalpha, and PPARgamma, showing significant stimulation in the tested models. It has notable anti-inflammatory properties, inhibiting cytokines such as TNF-alpha and enzymes involved in inflammation, like cyclooxygenase and lipoxygenase, in various assays. Its potential as a mitochondrial enzyme inhibitor and its inhibitory activity against pathways such as human EGFR reaffirm its diverse therapeutic potential.
The compound also demonstrated cytotoxicity against human KB cells and showed inhibitory effects on procoagulant activity and nitric oxide production in various cell models. Despite weak inhibitory activity for acetylcholinesterase and butyrylcholinesterase, it remains bioactive against several other targets, including FLT3 mutants in cancer cells, and exhibits antimicrobial activity against bacteria like Staphylococcus aureus.
Overall, Acacetin presents a promising candidate for therapeutic development due to its diverse biological activities across multiple pathways and cellular processes..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, exhibiting antinociceptive, anti-inflammatory, and antioxidant activities in different research models. |
| Synonyms | Linarigenin, 5,7-Dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin |
| Molecular Weight | 284.26 |
| Formula | C16H12O5 |
| Cas No. | 480-44-4 |
| Smiles | COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1 |
| Relative Density. | 1.42 g/cm3 |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble)  DMSO: 6.25 mg/mL (21.99 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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