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KPT185

Name: KPT185
Brand: TargetMol
SKU: T2425
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2425Cas No. 1333151-73-7

Alias KPT-185, KPT 185

KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

KPT185

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Purity: 98%

Catalog No. T2425Alias KPT-185, KPT 185Cas No. 1333151-73-7

KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

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Product Introduction

Bioactivity

Description	KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
Targets&IC50	CRM1:100-500nM
In vivo	In leukemia cells (IC50=100 nM-500 nM), KPT-185 significantly inhibited cell proliferation. In AML cell lines and primary AML mother cells, KPT-185 was able to arrest the cell cycle and induce apoptosis. In pancreatic cancer cells, KPT-185 inhibited cell proliferation and induced apoptosis, but KPT-185 did not affect the growth of human pancreatic ductal epithelial cells.
Cell Research	Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)
Synonyms	KPT-185, KPT 185

Chemical Properties

Molecular Weight	355.31
Formula	C₁₆H₁₆F₃N₃O₃
Cas No.	1333151-73-7
Smiles	COc1cc(cc(c1)C(F)(F)F)-c1ncn(C=CC(=O)OC(C)C)n1
Relative Density.	1.29 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL

DMSO: 66 mg/mL (185.75 mM), Sonication is recommended.

Ethanol: 66 mg/mL (185.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8144 mL	14.0722 mL	28.1444 mL	140.7222 mL
5 mM	0.5629 mL	2.8144 mL	5.6289 mL	28.1444 mL
10 mM	0.2814 mL	1.4072 mL	2.8144 mL	14.0722 mL
20 mM	0.1407 mL	0.7036 mL	1.4072 mL	7.0361 mL
50 mM	0.0563 mL	0.2814 mL	0.5629 mL	2.8144 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc