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KPT185

Name: KPT185
Brand: TargetMol
SKU: T2425
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2425Cas No. 1333151-73-7

Alias KPT-185, KPT 185

KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

KPT185

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Purity: 99.31%

Catalog No. T2425Alias KPT-185, KPT 185Cas No. 1333151-73-7

KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.31%

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
Targets&IC50	CRM1:100-500nM
In vivo	In leukemia cells (IC50=100 nM-500 nM), KPT-185 significantly inhibited cell proliferation. In AML cell lines and primary AML mother cells, KPT-185 was able to arrest the cell cycle and induce apoptosis. In pancreatic cancer cells, KPT-185 inhibited cell proliferation and induced apoptosis, but KPT-185 did not affect the growth of human pancreatic ductal epithelial cells.
Cell Research	Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference)
Synonyms	KPT-185, KPT 185

Chemical Properties

Molecular Weight	355.31
Formula	C₁₆H₁₆F₃N₃O₃
Cas No.	1333151-73-7
Smiles	COc1cc(cc(c1)C(F)(F)F)-c1ncn(C=CC(=O)OC(C)C)n1
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: <1 mg/mL

DMSO: 66 mg/mL (185.75 mM), Sonication is recommended.

Ethanol: 66 mg/mL (185.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8144 mL	14.0722 mL	28.1444 mL	140.7222 mL
5 mM	0.5629 mL	2.8144 mL	5.6289 mL	28.1444 mL
10 mM	0.2814 mL	1.4072 mL	2.8144 mL	14.0722 mL
20 mM	0.1407 mL	0.7036 mL	1.4072 mL	7.0361 mL
50 mM	0.0563 mL	0.2814 mL	0.5629 mL	2.8144 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4072 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc