Sterculic acid

Name: Sterculic acid
Brand: TargetMol
SKU: T41253
Rating: 4.5 (1 reviews)

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Catalog No. T41253Cas No. 738-87-4

Sterculic acid, a stearoyl-CoA desaturase-1 (SCD1) inhibitor, effectively suppresses delta-9 desaturase (Δ9D) activity in a dose-dependent manner, exhibiting an inhibition concentration (IC50) value of 0.9 μM [1].

Sterculic acid

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Catalog No. T41253Cas No. 738-87-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,880	35 days	35 days

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	Sterculic acid, a stearoyl-CoA desaturase-1 (SCD1) inhibitor, effectively suppresses delta-9 desaturase (Δ9D) activity in a dose-dependent manner, exhibiting an inhibition concentration (IC50) value of 0.9 μM [1].
Targets&IC50	Delta9 desaturase:0.9 μM
In vitro	Sterculic acid (SA), a cyclopropene fatty acid derived from Sterculia foetida seeds, exhibits diverse biological activities, including the reduction of adrenomedullin expression (AP, RP, APS, IML, in preparation) and mediating anti-inflammatory and protective effects. It also demonstrates a potent luteolytic effect in ovines by inhibiting progesterone synthesis, leading to luteal regression [2].
In vivo	Sterculic acid is suggested as a promising intervention for metabolic syndrome (MS), as it effectively inhibits the function of stearoyl-CoA desaturase-1 (SCD1) in vivo [3].

Chemical Properties

Molecular Weight	294.47
Formula	C₁₉H₃₄O₂
Cas No.	738-87-4
Smiles	C(CCCCCCC(O)=O)C1=C(CCCCCCCC)C1
Relative Density.	0.948 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc