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Anti-ER beta Antibody (4M551)
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Catalog No. TMAY-00093 Copy Product Info
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Anti-ER beta Antibody (4M551) is a Mouse antibody targeting ER beta. Anti-ER beta Antibody (4M551) can be used in ICC/IF.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $199 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Chemical Properties
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| Description | Anti-ER beta Antibody (4M551) is a Mouse antibody targeting ER beta. Anti-ER beta Antibody (4M551) can be used in ICC/IF. |
| Ig Type | Mouse IgG1 |
| Clone | 4M551 |
| Reactivity | Human |
| Specificity | Human ER beta |
| Application | |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human ER beta/ESR2. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. The development of endometriosis is associated with changes in the expression of genes encoding the 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) and 17beta-hydroxysteroid dehydrogenase type II (HSD17B2), estrogen receptors 1 (ESR1) and 2 (ESR2) and the androgen receptor (AR). Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation, that ESR2 regulates key genes in GCs that are essential for follicle maturation and ovulation in the rat. There is a strong association between ESR2 SNPs and BMD, indicating that ESR2 may influence attainment of bone mass. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: C-terminus of the Human ER beta/ESR2 |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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