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Anti-ER beta Antibody (4M551)
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Catalog No. TMAY-00093
Anti-ER beta Antibody (4M551) is a Mouse antibody targeting ER beta. Anti-ER beta Antibody (4M551) can be used in ICC/IF.
Anti-ER beta Antibody (4M551)
Anti-ER beta Antibody (4M551)
😃Good
Catalog No. TMAY-00093
Anti-ER beta Antibody (4M551) is a Mouse antibody targeting ER beta. Anti-ER beta Antibody (4M551) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ICC/IF Reactivity: Human |
| Ig Type | Mouse IgG1 |
| Clone | 4M551 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of ER beta in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with mouse anti-Human ER beta monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-mouse IgG secondary antibody (green). Positive staining was localized to Nucleus. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human ER beta/ESR2. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Estrogen signal medicated by estrogen receptor (ER), which is involved in various diseases related to steroid hormone, such as cancer. A number of association studies have focused on ESR2 polymorphisms to investigate the relationship with cancer risk. The development of endometriosis is associated with changes in the expression of genes encoding the 3beta-hydroxysteroid dehydrogenase type II (HSD3B2) and 17beta-hydroxysteroid dehydrogenase type II (HSD17B2), estrogen receptors 1 (ESR1) and 2 (ESR2) and the androgen receptor (AR). Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation, that ESR2 regulates key genes in GCs that are essential for follicle maturation and ovulation in the rat. There is a strong association between ESR2 SNPs and BMD, indicating that ESR2 may influence attainment of bone mass. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: C-terminus of the Human ER beta/ESR2 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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