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S107

Name: S107
Brand: TargetMol
SKU: T3438
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3438 Copy Product Info

Purity: 99.90%

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S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

S107

Copy Product Info

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Catalog No. T3438

S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

Cas No. 927871-76-9

Pack Size	Price	USA Stock	Global Stock
2 mg	$32	In Stock	-
5 mg	$58	In Stock	-
10 mg	$88	In Stock	-
25 mg	$160	In Stock	-
50 mg	$268	In Stock	-
100 mg	$382	In Stock	-
200 mg	$543	In Stock	-
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
In vitro	S107, a small compound, enhances calstabin2 binding to RyR2 at low nanomolar concentrations and does not interact with over 400 receptors, enzymes, and ion channels at up to 10 μM. It shows no effect on cardiac ion channels, including voltage-gated Na+, K+, and Ca2+ channels, or on normal Ca2+ signaling in cells[1]. S107 is a potential candidate for treating catecholaminergic polymorphic ventricular tachycardia (CPVT), exerting antiarrhythmic effects on CPVT-hiPSC-CMs. Pre-incubation with 10 μM S107 significantly reduces the incidence of CPVT-hiPSC-CMs presenting DADs to 25% by stabilizing the closed state of ryanodine receptor 2[2]. S107 may improve skeletal muscle function by stabilizing the RyR1-FKBP12 complex, increasing FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12 but not in the presence of oxidized glutathione. It reverses the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites[3].
In vivo	S107 effectively inhibits seizures and arrhythmias in mutant mice without blocking the channel or changing normal calcium (Ca2+) signaling; it specifically prevents leakage in the channel[1].

Chemical Properties

Molecular Weight	209.31
Formula	C₁₁H₁₅NOS
Cas No.	927871-76-9
Smiles	COc1ccc2SCCN(C)Cc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (621.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7776 mL	23.8880 mL	47.7760 mL	238.8801 mL
5 mM	0.9555 mL	4.7776 mL	9.5552 mL	47.7760 mL
10 mM	0.4778 mL	2.3888 mL	4.7776 mL	23.8880 mL
20 mM	0.2389 mL	1.1944 mL	2.3888 mL	11.9440 mL
50 mM	0.0956 mL	0.4778 mL	0.9555 mL	4.7776 mL
100 mM	0.0478 mL	0.2389 mL	0.4778 mL	2.3888 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc