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CLT-28643
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Catalog No. T71368Cas No. 1153631-91-4
Alias CLT28643
CLT-28643 is a potent and specific α5β1-Integrin inhibitor that prevents fibrosis in glaucoma filtration surgery (GFS), inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation in a bleomycin-induced lung fibrosis model, and improves insulin sensitivity and cardiac function in H9C2 cells from obese mice.
CLT-28643
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Purity: 99.89%
Catalog No. T71368Alias CLT28643Cas No. 1153631-91-4
CLT-28643 is a potent and specific α5β1-Integrin inhibitor that prevents fibrosis in glaucoma filtration surgery (GFS), inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation in a bleomycin-induced lung fibrosis model, and improves insulin sensitivity and cardiac function in H9C2 cells from obese mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | CLT-28643 is a potent and specific α5β1-Integrin inhibitor that prevents fibrosis in glaucoma filtration surgery (GFS), inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation in a bleomycin-induced lung fibrosis model, and improves insulin sensitivity and cardiac function in H9C2 cells from obese mice. |
| In vitro | In H9C2 cardiomyocytes, CLT-28643 (3 hours) was used to assess its effect on insulin signaling under metabolic stress, CLT-28643 prevented high glucose and palmitate-induced insulin resistance by significantly increasing the phosphorylated Akt (Ser473) to total Akt ratio, indicating restored insulin sensitivity. [1] |
| In vivo | In male C57BL/6 mice fed a high-fat-high-sucrose (HFHS) diet for 10 weeks, CLT-28643 (75 mg/kg; oral gavage; twice daily for 4 weeks) was administered to evaluate its cardiometabolic effect. CLT-28643 improved cardiac function by reversing the HFHS diet-induced elevation in heart rate, suggesting enhanced cardiovascular performance. [1] |
| Synonyms | CLT28643 |
| Molecular Weight | 351.36 |
| Formula | C19H17N3O4 |
| Cas No. | 1153631-91-4 |
| Smiles | O=C(O)C1=CN=C2C=CC(=CC2=C1NC3=CC=C(OC)C=C3)C(=O)NC |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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