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Aselizumab
😃Good
Catalog No. T78301Cas No. 395639-53-9
Alias HuDreg-55, HuDreg55
Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody that targets L-selectin (CD62L), a cell adhesion molecule found on circulating neutrophils. L-selectin plays a crucial role in directing cell migration through chemotaxis to injury sites. Aselizumab has been associated with an increased incidence of infections and leukopenia, particularly following trauma, suggesting potential safety concerns that need further investigation in clinical contexts.
Aselizumab
Aselizumab
😃Good
Purity: 95%
Catalog No. T78301Alias HuDreg-55, HuDreg55Cas No. 395639-53-9
Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody that targets L-selectin (CD62L), a cell adhesion molecule found on circulating neutrophils. L-selectin plays a crucial role in directing cell migration through chemotaxis to injury sites. Aselizumab has been associated with an increased incidence of infections and leukopenia, particularly following trauma, suggesting potential safety concerns that need further investigation in clinical contexts.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $298 | - | In Stock | |
| 5 mg | $688 | - | In Stock | |
| 10 mg | $1,090 | - | In Stock | |
| 25 mg | $1,660 | - | In Stock | |
| 50 mg | $2,230 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
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| Description | Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody that targets L-selectin (CD62L), a cell adhesion molecule found on circulating neutrophils. L-selectin plays a crucial role in directing cell migration through chemotaxis to injury sites. Aselizumab has been associated with an increased incidence of infections and leukopenia, particularly following trauma, suggesting potential safety concerns that need further investigation in clinical contexts. |
| In vitro | Aselizumab can form dimers through disulfide linkage with the light chains of the chimeric monoclonal HuDreg-55 [1]. At concentrations ranging from 5 to 500 ng/mL and after 25 minutes of incubation, aselizumab inhibits the L-selectin-dependent adhesion of human lymphocytes to high endothelial venules in frozen lymph node sections [3]. |
| In vivo | Aselizumab, administered intravenously at a single dose of 10 mg/kg in cynomolgus monkeys, exhibited an elimination half-life of 12.0 days [3]. |
| Synonyms | HuDreg-55, HuDreg55 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | L-selectin |
| Molecular Weight | 144.73 kDa |
| Cas No. | 395639-53-9 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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