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Aselizumab

Catalog No. T78301 CAS 395639-53-9

Synonyms: HuDreg-55

Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody (mAb) targeting L-selectin (CD62L), a cell adhesion molecule found on circulating neutrophils that directs cell migration through chemotaxis to injury sites. Notably, Aselizumab has been associated with an increased incidence of infections and leukopenia following trauma [1] [2].

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Aselizumab

Aselizumab, CAS 395639-53-9

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Description	Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody (mAb) targeting L-selectin (CD62L), a cell adhesion molecule found on circulating neutrophils that directs cell migration through chemotaxis to injury sites. Notably, Aselizumab has been associated with an increased incidence of infections and leukopenia following trauma [1] [2].
In vitro	Aselizumab can form dimers through disulfide linkage with the light chains of the chimeric monoclonal HuDreg-55 [1]. At concentrations ranging from 5 to 500 ng/mL and after 25 minutes of incubation, aselizumab inhibits the L-selectin-dependent adhesion of human lymphocytes to high endothelial venules in frozen lymph node sections [3].
In vivo	Aselizumab, administered intravenously at a single dose of 10 mg/kg in cynomolgus monkeys, exhibited an elimination half-life of 12.0 days [3].

Synonyms	HuDreg-55
Molecular Weight	N/A
CAS No.	395639-53-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Aselizumab 395639-53-9 HuDreg-55 inhibitor inhibit

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