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Anti-FGFR1 Antibody (7J437)
😃Good
Catalog No. TMAY-01029
Alias OGD, N-SAM, KAL2, HRTFDS, HH2, HBGFR, FLT-2, FLT2, FLG, fibroblast growth factor receptor 1, FGFR1 α (IIIc), FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR
Anti-FGFR1 Antibody (7J437) is a Mouse antibody targeting FGFR1. Anti-FGFR1 Antibody (7J437) can be used in IHC-P.
Anti-FGFR1 Antibody (7J437)
Anti-FGFR1 Antibody (7J437)
😃Good
Catalog No. TMAY-01029Alias OGD, N-SAM, KAL2, HRTFDS, HH2, HBGFR, FLT-2, FLT2, FLG, fibroblast growth factor receptor 1, FGFR1 α (IIIc), FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR
Anti-FGFR1 Antibody (7J437) is a Mouse antibody targeting FGFR1. Anti-FGFR1 Antibody (7J437) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | OGD, N-SAM, KAL2, HRTFDS, HH2, HBGFR, FLT-2, FLT2, FLG, fibroblast growth factor receptor 1, FGFR1 α (IIIc), FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR |
| Ig Type | Mouse IgG2a |
| Clone | 7J437 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of FGFR1 in pancreas with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of FGFR1 in lung carcinoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FGFR1 / CD331 (rh FGFR1 / CD331; TMPY-01011; NP_075594.1; Met1-Glu285). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glycosaminoglycans, which facilitates dimerization (activation) of FGF receptors. FGFR1 is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. CD331 can be detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells. Defects in FGFR1 are a cause of Pfeiffer syndrome ，idiopathic hypogonadotropic hypogonadism， Kallmann syndrome type 2, osteoglophonic dysplasia and trigonocephaly non-syndromic.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human FGFR1 / CD331 protein (TMPY-01011) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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