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DCPLA-ME

Name: DCPLA-ME
Brand: TargetMol
SKU: T10980
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoate, Methyl 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoate, DCPLA methyl ester, 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) Copy Product Info

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Synonyms: Methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoate, Methyl 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoate, DCPLA methyl ester, 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester

Catalog No. T10980 Copy Product Info

Purity: 99.80%

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DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA. DCPLA-ME is a highly selective PKCε activator with antioxidant and anti-inflammatory activities. DCPLA-ME can be used in research on neurodegenerative diseases.

Cas No. 56687-67-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$59	In Stock	In Stock
5 mg	$135	In Stock	In Stock
10 mg	$190	In Stock	In Stock
25 mg	$389	-	In Stock
50 mg	$636	-	In Stock
100 mg	$858	-	In Stock
200 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$148	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.80%

Appearance:Liquid

Color:Transparent

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA. DCPLA-ME is a highly selective PKCε activator with antioxidant and anti-inflammatory activities. DCPLA-ME can be used in research on neurodegenerative diseases.
In vivo	Methods: 16-month-old 3×Tg-AD mice (carrying APP/PS1/Tau triple mutations) and wild-type control mice were used. Multiple microinfarcts were induced in the brain by injecting approximately 2000 fluorescent microspheres (20 μm) into the right common carotid artery. Approximately 18 hours post-surgery, intraperitoneal injections of DCPLA-ME (3 mg/kg body weight, dissolved in sterile saline) were initiated at a frequency of three times weekly for two weeks. Control mice received an equal volume of solvent. Results: DCPLA-ME treatment significantly improved spatial memory deficits in 3×Tg+MI mice, reduced oxidative stress and apoptosis, alleviated persistent hypoxia, and protected microvascular structure, synapses, and myelin sheaths. [1]
Synonyms	Methyl 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoate, Methyl 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoate, DCPLA methyl ester, 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester

Chemical Properties

Molecular Weight	322.53
Formula	C₂₁H₃₈O₂
Cas No.	56687-67-3
Smiles	CCCCCC1CC1CC1CC1CCCCCCCC(=O)OC
Relative Density.	0.938 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (310.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1005 mL	15.5024 mL	31.0049 mL	155.0243 mL
5 mM	0.6201 mL	3.1005 mL	6.2010 mL	31.0049 mL
10 mM	0.3100 mL	1.5502 mL	3.1005 mL	15.5024 mL
20 mM	0.1550 mL	0.7751 mL	1.5502 mL	7.7512 mL
50 mM	0.0620 mL	0.3100 mL	0.6201 mL	3.1005 mL
100 mM	0.0310 mL	0.1550 mL	0.3100 mL	1.5502 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.