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PKC-IN-1

Name: PKC-IN-1
Brand: TargetMol
SKU: T12494
Rating: 4.5 (1 reviews)

Catalog No. T12494 Copy Product Info

Purity: 98.79%

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PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively).

PKC-IN-1

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Catalog No. T12494

Cas No. 1046787-18-1

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Pack Size	Price	USA Stock	Global Stock
2 mg	$198	8-10 weeks	8-10 weeks
5 mg	$347	8-10 weeks	8-10 weeks
25 mg	$1,140	8-10 weeks	8-10 weeks
50 mg	$1,490	8-10 weeks	8-10 weeks
100 mg	$1,990	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$383	8-10 weeks	8-10 weeks

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.79%

Appearance:Solid

Color:White

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COA HPLC

Product Introduction

Bioactivity

Description	PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively).
Targets&IC50	PKCα (human):10.4 nM (ki), PKCα (human):2.3 nM, PKCθ (human):25.6 nM, PKCβII (human):7.6 nM, PKCβ (human):5.3 nM (ki), PKCβI (human):8.1 nM, PKCμ (human):314 nM, PKCε (human):808 nM, PKCγ (human):57.5 nM
In vitro	PKC-IN-1 is a potent, ATP-competitive, and reversible of conventional PKC enzymes (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively) [1].
In vivo	In Lewis rats, PKC-IN-1 dose-dependently and significantly reduces maximum EAE severity and end severity in the autoimmune encephalitis (EAE) model [1].

Chemical Properties

Molecular Weight	500.61
Formula	C₂₅H₃₇FN₈O₂
Cas No.	1046787-18-1
Smiles	C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(Nc3nc(C)ncc3F)n[nH]c2C1(C)C
Relative Density.	1.253 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (49.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9976 mL	9.9878 mL	19.9756 mL	99.8781 mL
5 mM	0.3995 mL	1.9976 mL	3.9951 mL	19.9756 mL
10 mM	0.1998 mL	0.9988 mL	1.9976 mL	9.9878 mL
20 mM	0.0999 mL	0.4994 mL	0.9988 mL	4.9939 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc