OSMR Protein, Human, Recombinant (His) V2

Catalog No. TMPY-01305U

OSMR Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q99650-1.

OSMR Protein, Human, Recombinant (His) V2

Catalog No. TMPY-01305U

OSMR Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q99650-1.

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Product Information

Biological Activity	Immobilized Human OSMR, His Tag at 1 μg/ml (100 μl/Well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 4.4 ng/ml determined by ELISA.
Description	OSMR Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q99650-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q99650-1
Synonyms	PLCA1,OSMRB,oncostatin M receptor,IL-31RB
Construction	Glu28-Met740
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	82.2 kDa (Predicted); 110-140 kDa (Due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.