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L-2-Hydroxyglutaric acid

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Catalog No. T13749Cas No. 13095-48-2
Alias (S)-2-Hydroxyglutaric acid

L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

L-2-Hydroxyglutaric acid
Other Forms of L-2-Hydroxyglutaric acid:
L-2-Hydroxyglutaric acid disodiumT1374863512-50-5
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L-2-Hydroxyglutaric acid

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Catalog No. T13749Alias (S)-2-Hydroxyglutaric acidCas No. 13095-48-2
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$11335 days35 days
5 mg$28335 days35 days
10 mg$45035 days35 days
25 mgInquiry35 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Concentration:10 mg/mL
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Product Introduction

Bioactivity
Description
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
Targets&IC50
mitochondrial creatine kinase:2.52 mM (Km), mitochondrial creatine kinase:11.13 mM (Ki)
In vitro
L-2-Hydroxyglutaric acid exhibits potent inhibition of 2-oxoglutarate (2-OG)-dependent dioxygenases (2OGDs), including Ten Eleven Translocation (TET) enzymes. [1]
L-2-Hydroxyglutaric acid was able to effectively inhibit mitochondrial creatine kinase (Mi-CK) activity with a Km value of 2.52 mM and a Ki value of 11.13 mM. [2]
Synonyms(S)-2-Hydroxyglutaric acid
Chemical Properties
Molecular Weight148.11
FormulaC5H8O5
Cas No.13095-48-2
Smiles[C@H](CCC(O)=O)(C(O)=O)O
Relative Density.1.508 g/cm3 (Predicted)
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

L-2-Hydroxyglutaric acidL2Hydroxyglutaric acidL 2 Hydroxyglutaric acidHuman Endogenous Metabolite2-Hydroxyglutaric acid
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