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L-2-Hydroxyglutaric acid
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Catalog No. T13749Cas No. 13095-48-2
Alias (S)-2-Hydroxyglutaric acid
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
L-2-Hydroxyglutaric acid
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Catalog No. T13749Alias (S)-2-Hydroxyglutaric acidCas No. 13095-48-2
L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $113 | 35 days | 35 days | |
| 5 mg | $283 | 35 days | 35 days | |
| 10 mg | $450 | 35 days | 35 days | |
| 25 mg | Inquiry | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research. |
| Targets&IC50 | mitochondrial creatine kinase:11.13 mM (Ki), mitochondrial creatine kinase:2.52 mM (Km) |
| In vitro | L-2-Hydroxyglutaric acid exhibits potent inhibition of 2-oxoglutarate (2-OG)-dependent dioxygenases (2OGDs), including Ten Eleven Translocation (TET) enzymes. [1] L-2-Hydroxyglutaric acid was able to effectively inhibit mitochondrial creatine kinase (Mi-CK) activity with a Km value of 2.52 mM and a Ki value of 11.13 mM. [2] |
| Synonyms | (S)-2-Hydroxyglutaric acid |
| Molecular Weight | 148.11 |
| Formula | C5H8O5 |
| Cas No. | 13095-48-2 |
| Smiles | [C@H](CCC(O)=O)(C(O)=O)O |
| Relative Density. | 1.508 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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