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Anti-Cripto Antibody (6V546)
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Catalog No. TMAY-01320
Alias teratocarcinoma-derived growth factor 1, CRIPTO, CRGF, CR
Anti-Cripto Antibody (6V546) is a Mouse antibody targeting Cripto. Anti-Cripto Antibody (6V546) can be used in ELISA.
Anti-Cripto Antibody (6V546)
Anti-Cripto Antibody (6V546)
😃Good
Catalog No. TMAY-01320Alias teratocarcinoma-derived growth factor 1, CRIPTO, CRGF, CR
Anti-Cripto Antibody (6V546) is a Mouse antibody targeting Cripto. Anti-Cripto Antibody (6V546) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | teratocarcinoma-derived growth factor 1, CRIPTO, CRGF, CR |
| Ig Type | Mouse IgG1 |
| Clone | 6V546 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cripto / TDGF1 / CRGF (rh Cripto / TDGF1 / CRGF; TMPY-01413; AAH22393.1; Met1-Thr172). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Cripto / TDGF1 / CRGF Protein (TMPY-01413) |
| Antigen Species | Human |
| Biology Area | Cardiac Stem Cell Markers |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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