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Anti-FGF19 Antibody (1A6) represents a highly specialized monoclonal antibody specifically engineered to target the human fibroblast growth factor 19 with exceptional binding affinity. It effectively facilitates the measurable neutralization of FGF19-mediated signaling across various preclinical experimental models to evaluate the blockade of the FGFR4/beta-Klotho complex during strictly monitored laboratory observation periods and functional cell signaling assays to ensure high experimental sensitivity in molecular oncology.

| Description | Anti-FGF19 Antibody (1A6) represents a highly specialized monoclonal antibody specifically engineered to target the human fibroblast growth factor 19 with exceptional binding affinity. It effectively facilitates the measurable neutralization of FGF19-mediated signaling across various preclinical experimental models to evaluate the blockade of the FGFR4/beta-Klotho complex during strictly monitored laboratory observation periods and functional cell signaling assays to ensure high experimental sensitivity in molecular oncology. |
| In vitro | In human hepatocellular carcinoma cell lines (e.g., Hep3B), Anti-FGF19 Antibody (1A6) blocked FGF19-induced FGFR4 autophosphorylation and suppressed colony formation [1]. |
| In vivo | In human hepatocellular carcinoma xenograft models and FGF19 transgenic mice, systemic administration of Anti-FGF19 Antibody (1A6) significantly inhibited tumor growth [1]. |
| Synonyms | 1A6 |
| Clone | 1A6 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | FGF19 |
| Isotype | IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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