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Gamma-glutamylcysteine TFA

Name: Gamma-glutamylcysteine TFA
Brand: TargetMol
SKU: T11357
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11357Cas No. 283159-88-6

Alias γ-glutamylcysteine TFA

Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.

Gamma-glutamylcysteine TFA

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Purity: 99.83%

Catalog No. T11357Alias γ-glutamylcysteine TFACas No. 283159-88-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$44	-	In Stock
25 mg	$81	-	In Stock
50 mg	$135	-	In Stock
100 mg	$198	-	In Stock
200 mg	$296	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS MS

Product Introduction

Bioactivity

Description	Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.
In vitro	Gamma-glutamylcysteine TFA (20, 40, and 80 μM) pretreated L02 cells for 2 hours and exposed to ethanol for 24 hours. The results showed that γ-GC alleviated the oxidative stress and mitochondrial damage induced by alcohol by increasing the activity of GSH, SOD and mitochondrial membrane potential. [1] Gamma-glutamylcysteine TFA (0-160 μM,48h) alleviates TNBS-induced IBD by modulating macrophage polarization. [2]
In vivo	Gamma-glutamylcysteine TFA (600 mg/kg or 1200 mg/kg oral tube feeding) improved IBD survival and colon injury. [2]
Synonyms	γ-glutamylcysteine TFA

Chemical Properties

Molecular Weight	364.3
Formula	C₁₀H₁₅F₃N₂O₇S
Cas No.	283159-88-6
Smiles	C(C(O)=O)(F)(F)F.[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(O)=O)CS
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (219.6 mM), Sonication is recommended.

H2O: 80 mg/mL (219.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.7450 mL	13.7250 mL	27.4499 mL	137.2495 mL
5 mM	0.5490 mL	2.7450 mL	5.4900 mL	27.4499 mL
10 mM	0.2745 mL	1.3725 mL	2.7450 mL	13.7250 mL
20 mM	0.1372 mL	0.6862 mL	1.3725 mL	6.8625 mL
50 mM	0.0549 mL	0.2745 mL	0.5490 mL	2.7450 mL
100 mM	0.0274 mL	0.1372 mL	0.2745 mL	1.3725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc