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Gamma-glutamylcysteine TFA

Name: Gamma-glutamylcysteine TFA
Brand: TargetMol
SKU: T11357
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11357Cas No. 283159-88-6

Alias γ-glutamylcysteine TFA

Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.

Gamma-glutamylcysteine TFA

🥰Excellent

Purity: 99.83%

Catalog No. T11357Alias γ-glutamylcysteine TFACas No. 283159-88-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	-	In Stock
10 mg	$46	-	In Stock
25 mg	$85	-	In Stock
50 mg	$142	-	In Stock
100 mg	$208	-	In Stock
200 mg	$297	-	In Stock
1 mL x 10 mM (in DMSO)	$31	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

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COA LCMS MS

Product Introduction

Bioactivity

Description	Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.
In vitro	Gamma-glutamylcysteine TFA (20, 40, and 80 μM) pretreated L02 cells for 2 hours and exposed to ethanol for 24 hours. The results showed that γ-GC alleviated the oxidative stress and mitochondrial damage induced by alcohol by increasing the activity of GSH, SOD and mitochondrial membrane potential. [1] Gamma-glutamylcysteine TFA (0-160 μM,48h) alleviates TNBS-induced IBD by modulating macrophage polarization. [2]
In vivo	Gamma-glutamylcysteine TFA (600 mg/kg or 1200 mg/kg oral tube feeding) improved IBD survival and colon injury. [2]
Synonyms	γ-glutamylcysteine TFA

Chemical Properties

Molecular Weight	364.3
Formula	C₁₀H₁₅F₃N₂O₇S
Cas No.	283159-88-6
Smiles	C(C(O)=O)(F)(F)F.[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(O)=O)CS
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (219.60 mM), Sonication is recommended.

H2O: 80.00 mg/mL (219.60 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.7450 mL	13.7250 mL	27.4499 mL	137.2495 mL
5 mM	0.5490 mL	2.7450 mL	5.4900 mL	27.4499 mL
10 mM	0.2745 mL	1.3725 mL	2.7450 mL	13.7250 mL
20 mM	0.1372 mL	0.6862 mL	1.3725 mL	6.8625 mL
50 mM	0.0549 mL	0.2745 mL	0.5490 mL	2.7450 mL
100 mM	0.0274 mL	0.1372 mL	0.2745 mL	1.3725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc