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Gamma-glutamylcysteine TFA
🥰Excellent
Catalog No. T11357Cas No. 283159-88-6
Alias γ-glutamylcysteine TFA
Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.
Gamma-glutamylcysteine TFA
🥰Excellent
Purity: 99.83%
Catalog No. T11357Alias γ-glutamylcysteine TFACas No. 283159-88-6
Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $46 | In Stock | |
| 25 mg | $85 | In Stock | |
| 50 mg | $142 | In Stock | |
| 100 mg | $208 | In Stock | |
| 200 mg | $297 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock |
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Purity:99.83%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis. |
| In vitro | Gamma-glutamylcysteine TFA (20, 40, and 80 μM) pretreated L02 cells for 2 hours and exposed to ethanol for 24 hours. The results showed that γ-GC alleviated the oxidative stress and mitochondrial damage induced by alcohol by increasing the activity of GSH, SOD and mitochondrial membrane potential. [1] Gamma-glutamylcysteine TFA (0-160 μM,48h) alleviates TNBS-induced IBD by modulating macrophage polarization. [2] |
| In vivo | Gamma-glutamylcysteine TFA (600 mg/kg or 1200 mg/kg oral tube feeding) improved IBD survival and colon injury. [2] |
| Synonyms | γ-glutamylcysteine TFA |
| Molecular Weight | 364.3 |
| Formula | C10H15F3N2O7S |
| Cas No. | 283159-88-6 |
| Smiles | C(C(O)=O)(F)(F)F.[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(O)=O)CS |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (219.60 mM), Sonication is recommended. H2O: 80.00 mg/mL (219.60 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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