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WB518
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Catalog No. T209235
WB518 is a potent STAT3 inhibitor. It effectively suppresses STAT3 activity and the expression of keratin 17. By inhibiting STAT3 phosphorylation and keratin 17, WB518 can significantly alleviate imiquimod and TPA-induced psoriasis in animal models.
WB518
WB518
😃Good
Catalog No. T209235
WB518 is a potent STAT3 inhibitor. It effectively suppresses STAT3 activity and the expression of keratin 17. By inhibiting STAT3 phosphorylation and keratin 17, WB518 can significantly alleviate imiquimod and TPA-induced psoriasis in animal models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | WB518 is a potent STAT3 inhibitor. It effectively suppresses STAT3 activity and the expression of keratin 17. By inhibiting STAT3 phosphorylation and keratin 17, WB518 can significantly alleviate imiquimod and TPA-induced psoriasis in animal models. |
| In vitro | WB518 (5-25 μM) significantly reduces the mRNA and protein levels of keratin 17 (K17) in HaCaT cells by inhibiting the phosphorylation of STAT3 Tyr705 (Y705). |
| In vivo | Topical application of WB518 (at doses of 17.5 μg and 35 μg per site, daily for 5 days) alleviates TPA-induced psoriasis-like skin inflammation and significantly improves the phenotypic characteristics in a mouse model of psoriasis. |
| Formula | C20H16BrN5O5S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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