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1-Hydroxyoctadecane

Name: 1-Hydroxyoctadecane
Brand: TargetMol
SKU: T5295
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5295Cas No. 112-92-5

Alias Stearyl alcohol, Octadecanol, 1-Octadecanol

1-Hydroxyoctadecane (OctadecanolOctadecanol) is a fatty alcohol present in human and is normally incorporated into plasmalogen lipids. Sjogren-Larsson syndrome is defined by the triad of ichthyosis, mental retardation, and spasticity, and patients accumulate fatty alcohols such as Octadenol in the plasma and cultured fibroblasts.

1-Hydroxyoctadecane

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Purity: 99.91%

Catalog No. T5295Alias Stearyl alcohol, Octadecanol, 1-OctadecanolCas No. 112-92-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

1-Hydroxyoctadecane AI Summary

1-Hydroxyoctadecane has been tested for a variety of bioactivities across different assays. It exhibits a minimum inhibitory concentration (MIC) greater than 800.0 µg/mL against Staphylococcus aureus and Propionibacterium acnes, indicating limited effectiveness against these bacterial strains. It induces NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells with a required concentration greater than 10.0 µg/mL to double the enzyme activity. The compound shows moderate potency in several assays, including a qHTS assay for Lamin A Splicing (2.5 nM), general anesthetics (39810.7 nM), S16 Schwann cell PMP22 luciferase assay (32196.8 nM), and DNA re-replication in colon adenocarcinoma cells (13335.9 nM). It also inhibits human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 562.3 nM and blocks Ebola Virus entry with AC50 of 3981.1 nM and 3.981 µM in different assays. The compound shows fungitoxicity against Colletotrichum gloeosporioides with an EC50 greater than 225.0 µg/mL. Additionally, it enhances oxacillin-mediated antibacterial activity against methicillin-resistant Staphylococcus aureus with a MIC greater than 256.0 µg/mL and shows activity against SARS-CoV-2 by inhibiting the virus-induced cytotoxicity in Caco-2 cells with -3.72% inhibition at 10 µM and VERO-6 cells with 0.44% inhibition. It also inhibits SARS-CoV-2 3CL-Pro protease by 15.4% at 20 µM and demonstrates minor inhibitory activity against human HDAC6 with percentages of 10.76% and 1.31% for commercial and custom peptide substrate assays, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Hydroxyoctadecane (OctadecanolOctadecanol) is a fatty alcohol present in human and is normally incorporated into plasmalogen lipids. Sjogren-Larsson syndrome is defined by the triad of ichthyosis, mental retardation, and spasticity, and patients accumulate fatty alcohols such as Octadenol in the plasma and cultured fibroblasts.
Synonyms	Stearyl alcohol, Octadecanol, 1-Octadecanol

Chemical Properties

Molecular Weight	270.49
Formula	C₁₈H₃₈O
Cas No.	112-92-5
Smiles	C(CCCCCCCCC)CCCCCCCCO
Relative Density.	0.91. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 1.35 mg/mL (4.99 mM), Sonication is recommended.

Methanol: 10 mg/mL (36.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	3.6970 mL	18.4850 mL	36.9699 mL	184.8497 mL

Methanol

	1mg	5mg	10mg	50mg
5 mM	0.7394 mL	3.6970 mL	7.3940 mL	36.9699 mL
10 mM	0.3697 mL	1.8485 mL	3.6970 mL	18.4850 mL
20 mM	0.1848 mL	0.9242 mL	1.8485 mL	9.2425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc