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Etomoxir sodium salt
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Catalog No. T4535Cas No. 828934-41-4
Alias (R)-Etomoxir sodium salt
Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation (FAO). Etomoxir sodium salt has antitumor activity.
Etomoxir sodium salt
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Purity: 99.82%
Catalog No. T4535Alias (R)-Etomoxir sodium saltCas No. 828934-41-4
Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation (FAO). Etomoxir sodium salt has antitumor activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | In Stock | In Stock | |
| 2 mg | $36 | In Stock | In Stock | |
| 5 mg | $55 | In Stock | In Stock | |
| 10 mg | $89 | In Stock | In Stock | |
| 25 mg | $155 | In Stock | In Stock | |
| 50 mg | $278 | In Stock | In Stock | |
| 100 mg | $455 | In Stock | In Stock | |
| 200 mg | $669 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $61 | In Stock | In Stock |
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Purity:99.82%
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Etomoxir sodium salt ((R)-Etomoxir sodium salt) is a carnitine palmitoyltransferase 1a (CPT-1a) inhibitor that inhibits fatty acid oxidation (FAO). Etomoxir sodium salt has antitumor activity. |
| Targets&IC50 | Hepatocyte cells (rat):10 µM (fatty acid oxidation), KB cells:2.76 µM, faTT cellsy acid oxidation in Hepatocyte cells (human):0.1 µM, faTT cellsy acid oxidation in Hepatocyte cells (guinea pig):1 µM |
| In vitro | METHODS: BCa cell lines UM-UC-3 and T24 were treated with Etomoxir sodium salt (20-200 μM) for 24-72 h. Cell viability was examined using MTT.
RESULTS: Etomoxir inhibited the viability of UM-UC-3 and T24 cells in a dose-dependent manner. [1] METHODS: Human breast cancer cells MCF-7 and T47D were treated with Etomoxir sodium salt (0.1-50 μM) for 24 h. Cellular FAO activity was measured by 3H palmitic acid. RESULTS: Low micromolar concentrations of Etomoxir were sufficient to achieve maximal inhibition of FAO in MCF-7 and T47D cells. [2] |
| In vivo | METHODS: To test the antitumor activity in vivo, Etomoxir sodium salt (40 mg/kg) was intraperitoneally injected into BALB/c nude mice carrying human bladder cancer tumor T24 every two days for twenty days.
RESULTS: Etomoxir significantly inhibited tumor growth. [1] METHODS: To test the activity against multiple sclerosis, Etomoxir sodium salt (15 mg/kg) was intraperitoneally injected into a C57BL/6J mouse model of EAE induction once a week or every two days for two weeks. RESULTS: Etomoxir-treated mice showed reduced disease severity as well as reduced inflammation and demyelination. Disruption of fatty acid metabolism promotes downregulation of CNS inflammation and this metabolic pathway is a potential therapeutic target for multiple sclerosis. [3] |
| Synonyms | (R)-Etomoxir sodium salt |
| Molecular Weight | 320.74 |
| Formula | C15H18ClO4.Na |
| Cas No. | 828934-41-4 |
| Smiles | [Na+].[O-]C(=O)[C@@]1(CCCCCCOc2ccc(Cl)cc2)CO1 |
| Relative Density. | no data available |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.21 mg/mL (10.01 mM), Sonication is recommended.  H2O: 5 mg/mL (15.59 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | Saline: 3.5 mg/mL (10.91 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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