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Anti-Galectin-1 Antibody (6V681)
🥰Excellent
Catalog No. TMAY-03789
Anti-Galectin-1 Antibody (6V681) is a Mouse antibody targeting Galectin-1. Anti-Galectin-1 Antibody (6V681) can be used in ELISA.
Anti-Galectin-1 Antibody (6V681)
Anti-Galectin-1 Antibody (6V681)
🥰Excellent
Catalog No. TMAY-03789
Anti-Galectin-1 Antibody (6V681) is a Mouse antibody targeting Galectin-1. Anti-Galectin-1 Antibody (6V681) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Galectin-1 Antibody (6V681) is a Mouse antibody targeting Galectin-1. Anti-Galectin-1 Antibody (6V681) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 6V681 |
| Reactivity | Rat |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat Galectin-1 / LGALS1 (rR Galectin-1 / LGALS1; P11762; Ala2-Glu135). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumor growth has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation, and allergies as well as host-pathogen interactions. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Rat Galectin-1 / LGALS1 Protein |
| Antigen Species | Rat |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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