Larotinib mesylate hydrate

Name: Larotinib mesylate hydrate
Brand: TargetMol
SKU: T72207
Rating: 4.5 (1 reviews)

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Catalog No. T72207Cas No. 2097129-93-4

Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM.

Larotinib mesylate hydrate

😃Good

Catalog No. T72207Cas No. 2097129-93-4

Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM.

Pack Size	Price	Availability
25 mg	$766	1-2 weeks
50 mg	$995	1-2 weeks
100 mg	$1,740	1-2 weeks

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Product Introduction

Bioactivity

Description	Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI), primarily targeting EGFR with an IC50 value of 0.6 nM.
Targets&IC50	EGFR T790M:45.2 nM, EGFR L858R:0.563 nM, BTK:196 nM, HER2:253 nM, HER4:84 nM, IRAK1:167 nM, EGFR (WT):0.611 nM, EGFR (L861Q):0.423 nM, BLK:102 nM

Chemical Properties

Molecular Weight	699.17
Formula	C₂₆H₃₆ClFN₄O₁₁S₂
Cas No.	2097129-93-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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