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Ophthalmic acid

Name: Ophthalmic acid
Brand: TargetMol
SKU: T33813
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T33813 Copy Product Info

Purity: 99.98%

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Ophthalmic acid is a ubiquitous metabolite and glutathione modulator with a Ki value of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), and non-selective cation channels. Ophthalmic acid is applicable to diabetes-related investigations and is particularly valuable for studies involving oxidative stress, glutathione metabolism, redox regulation, and metabolic dysfunction.

Cas No. 495-27-2

Pack Size	Price	USA Stock	Global Stock
5 mg	$35	-	In Stock
10 mg	$60	-	In Stock
25 mg	$123	-	In Stock
50 mg	$197	-	In Stock
100 mg	$293	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

Ophthalmic acid (5 μM) induces glutathione reductases, inhibits glutaredoxins by approximately 60% at 5 μM, and affects glutathione S-transferases when present at millimolar concentrations, while showing no effect on glutathione peroxidases[1].
Ophthalmic acid inhibits the activation of non-selective cation channels by intracellular NAD+ via mimicry of GSH's tripeptide structure[1].
Ophthalmic acid acts as a competitive inhibitor of GSH uptake[1].

Chemical Properties

Molecular Weight	289.29
Formula	C₁₁H₁₉N₃O₆
Cas No.	495-27-2
Smiles	[C@H](C(NCC(O)=O)=O)(NC(CC[C@@H](C(O)=O)N)=O)CC
Relative Density.	1.384g/cm3

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (276.54 mM), Sonication is recommended.

DMSO: 80 mg/mL (276.54 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4567 mL	17.2837 mL	34.5674 mL	172.8369 mL
5 mM	0.6913 mL	3.4567 mL	6.9135 mL	34.5674 mL
10 mM	0.3457 mL	1.7284 mL	3.4567 mL	17.2837 mL
20 mM	0.1728 mL	0.8642 mL	1.7284 mL	8.6418 mL
50 mM	0.0691 mL	0.3457 mL	0.6913 mL	3.4567 mL
100 mM	0.0346 mL	0.1728 mL	0.3457 mL	1.7284 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc