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KM04416 (Alias: KM 04416)

Name: KM04416
Brand: TargetMol
SKU: T73442
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T73442 Copy Product Info

Purity: 99.88%

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KM04416 is a GPD2 inhibitor that inhibits LUAD progression by modulating immune cell infiltration.

KM04416

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Catalog No. T73442

Alias KM 04416

KM04416 is a GPD2 inhibitor that inhibits LUAD progression by modulating immune cell infiltration.

Cas No. 26530-26-7

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$99	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.88%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	KM04416 is a GPD2 inhibitor that inhibits LUAD progression by modulating immune cell infiltration.
In vitro	KM04416 (20 µM, 48 h) was able to show growth inhibition on a variety of cancer cell lines. KM04416 (10 µM, 72 h) significantly reduced the proliferation of PNT1A cells.[1]
Synonyms	KM 04416

Chemical Properties

Molecular Weight	249.29
Formula	C₁₂H₁₁NO₃S
Cas No.	26530-26-7
Smiles	O=C(OCC)C1=CC=C(C=C1)N2SC=CC2=O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (160.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (8.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0114 mL	20.0570 mL	40.1139 mL	200.5696 mL
5 mM	0.8023 mL	4.0114 mL	8.0228 mL	40.1139 mL
10 mM	0.4011 mL	2.0057 mL	4.0114 mL	20.0570 mL
20 mM	0.2006 mL	1.0028 mL	2.0057 mL	10.0285 mL
50 mM	0.0802 mL	0.4011 mL	0.8023 mL	4.0114 mL
100 mM	0.0401 mL	0.2006 mL	0.4011 mL	2.0057 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc