Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1]. |
In vitro | Antileishmanial agent-16 administered at 0-20 µM for 24 hours exhibits potent anti-promastigote and amastigote activities against L. major with respective IC 50 values of 0.59 µM and 0.81 µM [1]. The compound demonstrates high selectivity towards L. amastigote and safety towards mammalian cells (VERO cells), as evidenced by a selectivity index (SI) of 311.4 [1]. The SI is the ratio of in vitro cytotoxicity (CC 50 in µM) to the antileishmanial activity against amastigotes (IC 50 in µM). |
Molecular Weight | 495.61 |
Formula | C27H37N5O4 |
CAS No. | 2934738-41-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antileishmanial agent-16 2934738-41-5 Microbiology/Virology Parasite inhibitor inhibit