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SMAD3 Protein, Human, Recombinant (His & Flag)
(Synonyms: SMAD3, SMAD family member 3, SMAD 3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, MADH3, Mad3, MAD homolog 3, JV15-2, hSMAD3, hMAD-3) Copy Product InfoSynonyms: SMAD3, SMAD family member 3, SMAD 3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, MADH3, Mad3, MAD homolog 3, JV15-2, hSMAD3, hMAD-3
Catalog No. TMPJ-00271 Copy Product Info
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. It also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $68 | 7-10 days | 7-10 days | |
| 10 μg | $110 | 7-10 days | 7-10 days | |
| 20 μg | $169 | 7-10 days | 7-10 days | |
| 50 μg | $310 | 7-10 days | 7-10 days | |
| 100 μg | $485 | 7-10 days | 7-10 days | |
| 200 μg | $762 | 7-10 days | 7-10 days | |
| 500 μg | $1,390 | 7-10 days | 7-10 days | |
| 1 mg | $1,980 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. It also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-6xHis-Flag |
| Accession Number | P84022 |
| Amino Acid | Ser2-Ser425 |
| Construction | Ser2-Ser425 |
| Protein Purity | Greater than 85% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 500 mM NaCl, 10% Glycerol, 2 mM EDTA, pH 8.0. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | SMAD3, SMAD family member 3, SMAD 3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, MADH3, Mad3, MAD homolog 3, JV15-2, hSMAD3, hMAD-3 |
| Research Background |
| Molecular Weight | 50-60 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: SMAD3 Protein, Human, Recombinant (His & Flag) chemical structure | SMAD3 Protein, Human, Recombinant (His & Flag) molecular weight
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