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CID5721353

Name: CID5721353
Brand: TargetMol
SKU: T3940
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3940Cas No. 301356-95-6

Alias BCL6 inhibitor

CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove.

CID5721353

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Purity: 98.90%

Catalog No. T3940Alias BCL6 inhibitorCas No. 301356-95-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$76	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$233	In Stock	In Stock
100 mg	$349	In Stock	In Stock
200 mg	$497	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.90%

Appearance:Solid

Color:Red

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COA HNMR LCMS

Product Introduction

CID5721353 AI Summary

CID5721353 exhibits bioactivity through the inhibition of the protein-protein interaction of C-terminal biotin-labelled BCoR with the wild-type BCL6 BTB domain, as indicated by an IC50 of 200,000.0 nM in an ELISA assay. It also displaces A488-SMRT from the BCL6 BTB domain with an IC50 of 212,000.0 nM and shows a binding affinity to the recombinant RED-NHS-labelled BCL6 BTB domain with a Kd of 129,000.0 nM, as determined by the microscale thermophoresis method. This compound has potential implications in the regulation of BCL6 protein function, targeting specifically its lateral groove, although another source suggests a slightly different Kd value of 138,000.0 nM for binding affinity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove.
Targets&IC50	Bcl-6:212 μM
Synonyms	BCL6 inhibitor

Chemical Properties

Molecular Weight	457.28
Formula	C₁₅H₉BrN₂O₆S₂
Cas No.	301356-95-6
Smiles	OC(=O)CC(N1C(=S)S\C(C1=O)=C1\C(=O)Nc2ccc(Br)cc12)C(O)=O
Relative Density.	2.06 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (131.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1868 mL	10.9342 mL	21.8684 mL	109.3422 mL
5 mM	0.4374 mL	2.1868 mL	4.3737 mL	21.8684 mL
10 mM	0.2187 mL	1.0934 mL	2.1868 mL	10.9342 mL
20 mM	0.1093 mL	0.5467 mL	1.0934 mL	5.4671 mL
50 mM	0.0437 mL	0.2187 mL	0.4374 mL	2.1868 mL
100 mM	0.0219 mL	0.1093 mL	0.2187 mL	1.0934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc