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Anti-CXCR2 Polyclonal Antibody (Synonyms: WHIMS2, IL8RB, IL8RA, IL8R2, CMKAR2, CDw128b, CD182)
Catalog No. TMAB-00506 Copy Product Info
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Anti-CXCR2 Polyclonal Antibody is a Rabbit antibody targeting CXCR2. Anti-CXCR2 Polyclonal Antibody can be used in WB.
Anti-CXCR2 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-00506
Synonyms WHIMS2, IL8RB, IL8RA, IL8R2, CMKAR2, CDw128b, CD182
Anti-CXCR2 Polyclonal Antibody is a Rabbit antibody targeting CXCR2. Anti-CXCR2 Polyclonal Antibody can be used in WB.
Anti-CXCR2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-CXCR2 Polyclonal Antibody is a Rabbit antibody targeting CXCR2. Anti-CXCR2 Polyclonal Antibody can be used in WB. |
| Synonyms | WHIMS2, IL8RB, IL8RA, IL8R2, CMKAR2, CDw128b, CD182 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Sample: Lane 1: Raw264.7 (Mouse) Cell Lysate at 30 μg Lane 2: U937 (Human) Cell Lysate at 30 μg Primary: Anti-CXCR2 (TMAB-00506) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45/55 kDa Observed band size: 59 kDa 2. Sample: Lane 1: Human THP-1 cell lysates Lane 2: Human U937 cell lysates Lane 3: Human HL60 cell lysates Lane 4: Human HepG2 cell lysates Primary: Anti-CXCR2 (TMAB-00506) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 55 kDa   |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]. |
| Immunogen | KLH conjugated synthetic peptide: human CXCR2 |
| Antigen Species | Human |
| Gene Name | CXCR2 |
| Gene ID | |
| Protein Name | C-X-C chemokine receptor type 2 |
| Uniprot ID | |
| Biology Area | GPCR,SARS Coronavirus,Other cell division antibodies |
| Function | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| Molecular Weight | Theoretical: 41 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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