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PFM03 is an endonuclease inhibitor that specifically blocks Mre11 and is also able to reduce MRN endonuclease activity by 98%, blocking hMRN-mediated endonucleotomy and nuclear exocytosis processes on the protein-binding end of the 5 ' and 3 ' chains.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $193 | In Stock | |
5 mg | $479 | In Stock | |
10 mg | $686 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $432 | In Stock |
Description | PFM03 is an endonuclease inhibitor that specifically blocks Mre11 and is also able to reduce MRN endonuclease activity by 98%, blocking hMRN-mediated endonucleotomy and nuclear exocytosis processes on the protein-binding end of the 5 ' and 3 ' chains. |
In vitro | Treatment with 50–400 μM PFM03 for 30 minutes specifically inhibits the endonuclease activity of MRE11 [1]. Treatment with 100 μM PFM03 for 30 minutes does not impair double-strand break (DSB) repair in G2-phase (CENPF⁺) cells [1]. Treatment with 50 μM PFM03 for 8 hours increases non-homologous end joining (NHEJ) activity while suppressing homologous recombination (HR) in cells [1]. |
Alias | PFM 03 |
Molecular Weight | 293.4 |
Formula | C14H15NO2S2 |
Cas No. | 1558598-48-3 |
Smiles | C(=C\1/C(=O)N(C(CC)C)C(=S)S1)\C2=CC=C(O)C=C2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (272.67 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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