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lavendustin C

Name: lavendustin C
Brand: TargetMol
SKU: T4185
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4185Cas No. 125697-93-0

Alias NSC 666251, HDBA

lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.

lavendustin C

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Purity: 98.06%

Catalog No. T4185Alias NSC 666251, HDBACas No. 125697-93-0

lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
2 mg	$53	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$367	In Stock	In Stock
50 mg	$546	In Stock	In Stock
100 mg	$786	-	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.06%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

lavendustin C AI Summary

lavendustin C exhibits a diverse range of bioactivities with significant potency as an inhibitor of several protein tyrosine kinases. It shows an IC50 of 30.0 nM for inhibition of tyrosine kinase activity by competing with the RRSrc peptide and an IC50 of 4,000 nM for inhibiting epidermal growth factor receptor (EGFR) autophosphorylation. Additionally, it inhibits p56lck autophosphorylation and protein-tyrosine kinase p56lck with IC50 values of 10,000 nM. Besides its kinase inhibitory activity, it affects EGF-dependent DNA synthesis in ER22 cells with an IC50 of 92,000 nM and expresses cytotoxicity against human HaCaT and HEK293 cells with IC50 values greater than 100,000 nM. lavendustin C also impacts NOX4 activity in HEK293 FS cells, inhibiting H2O2 production with an IC50 of 1,340 nM. Furthermore, it demonstrates inhibitory activity against various other biological targets, offering potential for broad-spectrum therapeutic applications in nanomolar to micromolar potency ranges..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
Targets&IC50	CaMK II:0.2 μM (IC50), EGFR:0.012 μM (IC50)
Synonyms	NSC 666251, HDBA

Chemical Properties

Molecular Weight	275.26
Formula	C₁₄H₁₃NO₅
Cas No.	125697-93-0
Smiles	N(CC1=C(O)C=CC(O)=C1)C2=CC(C(O)=O)=C(O)C=C2
Relative Density.	1.551 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (217.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6329 mL	18.1646 mL	36.3293 mL	181.6464 mL
5 mM	0.7266 mL	3.6329 mL	7.2659 mL	36.3293 mL
10 mM	0.3633 mL	1.8165 mL	3.6329 mL	18.1646 mL
20 mM	0.1816 mL	0.9082 mL	1.8165 mL	9.0823 mL
50 mM	0.0727 mL	0.3633 mL	0.7266 mL	3.6329 mL
100 mM	0.0363 mL	0.1816 mL	0.3633 mL	1.8165 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc