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PROTAC Mcl1 degrader-1

Name: PROTAC Mcl1 degrader-1
Brand: TargetMol
SKU: T11975
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11975Cas No. 2163793-38-0

PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC), a selective Mcl-1 inhibitor. By hijacking the CRBN ubiquitin ligase to form a ternary complex with the target protein, it induces Mcl-1 ubiquitination. It can be used for cancer research.

PROTAC Mcl1 degrader-1

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Purity: 98.74%

Catalog No. T11975Cas No. 2163793-38-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$79	-	In Stock
5 mg	$189	-	In Stock
10 mg	$318	-	In Stock
25 mg	$673	-	In Stock
50 mg	$1,080	-	In Stock
100 mg	$1,730	-	In Stock
200 mg	$2,330	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.74%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC), a selective Mcl-1 inhibitor. By hijacking the CRBN ubiquitin ligase to form a ternary complex with the target protein, it induces Mcl-1 ubiquitination. It can be used for cancer research.
Targets&IC50	Bcl-2:0.54 μM, MCL1:0.78 μM
In vitro	PROTAC Mcl1 degrader-1 (Compound C3) induces ubiquitination of Mcl-1 and promotes its proteasomal degradation by binding the Mcl-1 inhibitor S1-6 (with μM range affinity) to the E3 ligase cereblon (CRBN) ligand, pomalidomide.PROTAC Mcl1 degrader-1 selectively targets Mcl-1, a member of the Bcl-2 family, with an IC50 of 078 μM. PROTAC Mcl1 degrader-1 selectively targets Mcl-1 (a member of the Bcl-2 family) with an IC50 of 0.78 μM, and also inhibits Bcl-2 with an IC50 of 0.54 μM. [1] PROTAC Mcl1 degrader-1 (0-10 μM; 0-24 hours) selectively reduces Mcl-1 and Bcl-2 protein levels in HeLa cells by a time- and concentration-dependent mechanism. [1] PROTAC Mcl1 degrader-1 (0-2 μM; 24 hours) exhibits cytotoxic effects on H23 cells. [1]

Chemical Properties

Molecular Weight	909.84
Formula	C₄₅H₄₅BrN₆O₈S
Cas No.	2163793-38-0
Smiles	O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=CC=CC=6C(SC7=CC=C(Br)C=C7)=CC=C(C4=O)C56)C3C2=O)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (43.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0991 mL	5.4955 mL	10.9909 mL	54.9547 mL
5 mM	0.2198 mL	1.0991 mL	2.1982 mL	10.9909 mL
10 mM	0.1099 mL	0.5495 mL	1.0991 mL	5.4955 mL
20 mM	0.0550 mL	0.2748 mL	0.5495 mL	2.7477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc