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PF-06456384 trihydrochloride

Name: PF-06456384 trihydrochloride
Brand: TargetMol
SKU: T73846
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T73846Cas No. 1834610-75-1

Alias PF06456384 trihydrochloride

PF-06456384 trihydrochloride is a highly efficient and selective NaV1.7 inhibitor (IC50 = 0.01 nM), acting through protein-ligand binding rather than inhibiting the associated sodium channel. It is specifically designed for intravenous infusion and can be used in pain research.

PF-06456384 trihydrochloride

🥰Excellent

Purity: 99.16%

Catalog No. T73846Alias PF06456384 trihydrochlorideCas No. 1834610-75-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$81	-	In Stock
10 mg	$147	-	In Stock
25 mg	$313	-	In Stock
50 mg	$553	-	In Stock
100 mg	$959	-	In Stock
1 mL x 10 mM (in DMSO)	$133	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.16%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF-06456384 trihydrochloride is a highly efficient and selective NaV1.7 inhibitor (IC50 = 0.01 nM), acting through protein-ligand binding rather than inhibiting the associated sodium channel. It is specifically designed for intravenous infusion and can be used in pain research.
Targets&IC50	NaV1.7:0.01 nM
Synonyms	PF06456384 trihydrochloride

Chemical Properties

Molecular Weight	829.18
Formula	C₃₅H₃₅Cl₃F₃N₇O₃S₂
Cas No.	1834610-75-1
Smiles	N#CC1=CC(S(=O)(NC2=NC=NS2)=O)=CC=C1OC3=CC=C(C4=CC(C(F)(F)F)=CC=C4)C=C3C5=CC(CNCCC6CCNCC6)=NC=C5.Cl.Cl.Cl
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (120.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2060 mL	6.0301 mL	12.0601 mL	60.3005 mL
5 mM	0.2412 mL	1.2060 mL	2.4120 mL	12.0601 mL
10 mM	0.1206 mL	0.6030 mL	1.2060 mL	6.0301 mL
20 mM	0.0603 mL	0.3015 mL	0.6030 mL	3.0150 mL
50 mM	0.0241 mL	0.1206 mL	0.2412 mL	1.2060 mL
100 mM	0.0121 mL	0.0603 mL	0.1206 mL	0.6030 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc