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Mavoglurant
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Catalog No. T11951LCas No. 543906-09-8
Alias AFQ-056, AFQ056, AFQ 056
Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinson’s disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide–alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies.
Mavoglurant
😃Good
Catalog No. T11951LAlias AFQ-056, AFQ056, AFQ 056Cas No. 543906-09-8
Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinson’s disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide–alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $347 | - | In Stock | |
| 50 mg | $1,490 | - | In Stock | |
| 100 mg | $1,990 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $382 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinson’s disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide–alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies. |
| Targets&IC50 | mGluR5 (rat):47 nM |
| In vitro | In functional assays using L(tk-) cells expressing human mGluR5a, Mavoglurant antagonized agonist-induced signaling, inhibiting phosphoinositide turnover (IC50 = 30 nM) and intracellular Ca2+ mobilization (IC50 = 110 nM). Radioligand binding assays confirmed its interaction with the transmembrane allosteric site by displacing 3H-AAE327 with an IC50 of 47 nM [1]. |
| In vivo | In a mouse model of Stress-Induced Hyperthermia (SIH), oral administration of Mavoglurant (0.1 - 10 mg/kg) attenuated the stress response in a dose-dependent manner. Pharmacokinetic analysis in rats shows that the compound penetrates the blood-brain barrier; following intravenous injection (3.1 mg/kg), the Cmax in the brain (8400 pmol/g) was higher than in plasma (3330 pmol/mL). Oral administration (9.4 mg/kg) in rats demonstrated a bioavailability of 32% with a terminal half-life (T1/2) of 2.9 hours [1]. |
| Synonyms | AFQ-056, AFQ056, AFQ 056 |
| Molecular Weight | 313.39 |
| Formula | C19H23NO3 |
| Cas No. | 543906-09-8 |
| Smiles | C(#CC1=CC(C)=CC=C1)[C@@]2(O)[C@]3([C@](N(C(OC)=O)CC3)(CCC2)[H])[H] |
| Relative Density. | 1.21 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (319.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.53 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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