ABBV-4083 is a Tylosin A analog that has potent anti-Wolbachia and anti-filarial activity.

ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels in mice by >99.9% in recovered female adult worms (measured 16 weeks post-treatment-initiation). Circulating microfilariae levels begin to decline by approximately 7 weeks post-treatment-initiation (pti) and are completely cleared from 12 weeks pti until the study's end at 16 weeks pti.

Animal Model: Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites. Dosage: 150 mg/kg. Administration: PO once daily for 14 days started at 14 weeks post-infection (pti).