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Benazeprilat
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Catalog No. T19722Cas No. 86541-78-8
Alias CGS-14831, CGS14831, CGS 14831
Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination with other classes of compounds, including thiazide diuretics and calcium channel blockers, to reduce the incidence of diseases associated with cardiovascular risk and secondary end-organ damage.Benazeprilat may be be used to study acute left ventricular failure.
Benazeprilat
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Purity: 99.23%
Catalog No. T19722Alias CGS-14831, CGS14831, CGS 14831Cas No. 86541-78-8
Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination with other classes of compounds, including thiazide diuretics and calcium channel blockers, to reduce the incidence of diseases associated with cardiovascular risk and secondary end-organ damage.Benazeprilat may be be used to study acute left ventricular failure.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $73 | - | In Stock | |
| 5 mg | $259 | - | In Stock | |
| 10 mg | $429 | - | In Stock | |
| 25 mg | $686 | - | In Stock | |
| 50 mg | $972 | - | In Stock | |
| 100 mg | $1,280 | - | In Stock | |
| 200 mg | $1,760 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.23%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination with other classes of compounds, including thiazide diuretics and calcium channel blockers, to reduce the incidence of diseases associated with cardiovascular risk and secondary end-organ damage.Benazeprilat may be be used to study acute left ventricular failure. |
| In vivo | Benazeprilat (10 mg/kg; intravenous injection; once a day for 2 days; Male SHR) and amlodipine (0.5 mg/kg, intravenous injection) in combination produce a great hypotensive effect.[2] Benazepril (0.7 mg/kg; oral) significantly alters the dynamics of systemic RAAS peptides, leading to a considerable reduction in AII and ALD, while concurrently elevating PRA and AI.[3] |
| Synonyms | CGS-14831, CGS14831, CGS 14831 |
| Molecular Weight | 396.44 |
| Formula | C22H24N2O5 |
| Cas No. | 86541-78-8 |
| Smiles | C(C(O)=O)N1C=2C(CC[C@H](N[C@@H](CCC3=CC=CC=C3)C(O)=O)C1=O)=CC=CC2 |
| Relative Density. | 1.34 g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble)  DMSO: 1 mg/mL (2.52 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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