Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

CBR-5884

Name: CBR-5884
Brand: TargetMol
SKU: T14884
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T14884Cas No. 681159-27-3

CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH

CBR-5884

😃Good

Purity: 99.97%

Catalog No. T14884Cas No. 681159-27-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	Inquiry	Inquiry
5 mg	$60	In Stock	In Stock
10 mg	$92	In Stock	In Stock
25 mg	$217	In Stock	In Stock
50 mg	$375	In Stock	In Stock
100 mg	$560	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.97%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH
Targets&IC50	PHGDH:33 μM
In vitro	CBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits the proliferation of breast cancer lines with high serine synthesis propensity, as well as melanoma.

Chemical Properties

Molecular Weight	336.39
Formula	C₁₄H₁₂N₂O₄S₂
Cas No.	681159-27-3
Smiles	CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
Relative Density.	1.43 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 47 mg/mL (139.72 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.95 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9727 mL	14.8637 mL	29.7274 mL	148.6370 mL
5 mM	0.5945 mL	2.9727 mL	5.9455 mL	29.7274 mL
10 mM	0.2973 mL	1.4864 mL	2.9727 mL	14.8637 mL
20 mM	0.1486 mL	0.7432 mL	1.4864 mL	7.4318 mL
50 mM	0.0595 mL	0.2973 mL	0.5945 mL	2.9727 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4864 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc