Shopping Cart

Your shopping cart is currently empty

CAY 10465

Name: CAY 10465
Brand: TargetMol
SKU: T4607
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4607Cas No. 688348-33-6

Alias CAY10465 Exclusive, CAY10465

CAY 10465 is a selective and high-affinity AhR agonist with a Ki of 0.2 nM, and it shows no effect on the estrogen receptor (Ki >100000 nM).

CAY 10465

Copy Product Info

🥰Excellent

Purity: 98.80%

Catalog No. T4607Alias CAY10465 Exclusive, CAY10465Cas No. 688348-33-6

CAY 10465 is a selective and high-affinity AhR agonist with a Ki of 0.2 nM, and it shows no effect on the estrogen receptor (Ki >100000 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$70	In Stock	In Stock
10 mg	$112	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$453	In Stock	In Stock
100 mg	$687	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.80%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

CAY 10465 AI Summary

CAY 10465 is a potent agonist for the aryl hydrocarbon receptor (AhR) with a binding affinity (Ki value) of 0.2 nM. It does not show any significant binding affinity for estrogen receptor (ER) alpha. Additionally, it does not exhibit cytotoxicity towards human lung carcinoma (A549 cell line) or human breast cancer cell lines (MCF-7 and T47D) at concentrations tested up to 10.0 µM. This suggests that CAY 10465 specifically interacts with AhR, potentially affecting downstream signaling pathways and biological responses mediated by this receptor without causing cytotoxicity in these cancer cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CAY 10465 is a selective and high-affinity AhR agonist with a Ki of 0.2 nM, and it shows no effect on the estrogen receptor (Ki >100000 nM).
Targets&IC50	ERR:>100000 nM(Ki), AhR:0.2 nM(Ki)
Synonyms	CAY10465 Exclusive, CAY10465

Chemical Properties

Molecular Weight	317.13
Formula	C₁₅H₉Cl₂F₃
Cas No.	688348-33-6
Smiles	FC(F)(F)c1ccc(\C=C\c2cc(Cl)cc(Cl)c2)cc1
Relative Density.	1.378 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (315.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1533 mL	15.7664 mL	31.5328 mL	157.6640 mL
5 mM	0.6307 mL	3.1533 mL	6.3066 mL	31.5328 mL
10 mM	0.3153 mL	1.5766 mL	3.1533 mL	15.7664 mL
20 mM	0.1577 mL	0.7883 mL	1.5766 mL	7.8832 mL
50 mM	0.0631 mL	0.3153 mL	0.6307 mL	3.1533 mL
100 mM	0.0315 mL	0.1577 mL	0.3153 mL	1.5766 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc