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Cyclo(RGDyK) trifluoroacetate

Name: Cyclo(RGDyK) trifluoroacetate
Brand: TargetMol
SKU: T6813
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6813Cas No. 250612-42-1

Alias Cyclo(RGDyK)

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Cyclo(RGDyK) trifluoroacetate

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Purity: 95.28%

Catalog No. T6813Alias Cyclo(RGDyK)Cas No. 250612-42-1

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$147	In Stock
25 mg	$297	In Stock
50 mg	$488	In Stock
100 mg	$712	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock

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Batch Information

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Purity:95.28%

Resource Download

COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Targets&IC50	αvβ3 integrin:20 nM
In vitro	Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]
In vivo	In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]
Synonyms	Cyclo(RGDyK)

Chemical Properties

Molecular Weight	847.72
Formula	C₃₁H₄₃F₆N₉O₁₂
Cas No.	250612-42-1
Smiles	OC(C(F)(F)F)=O.NCCCC[C@@H]1NC([C@H](NC([C@@H](NC(CNC([C@@H](NC1=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC2=CC=C(C=C2)O)=O.OC(C(F)(F)F)=O
Relative Density.	no data available
Color	White
Appearance	Solid
Sequence Short	RGDYK

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (153.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1796 mL	5.8982 mL	11.7963 mL	58.9817 mL
5 mM	0.2359 mL	1.1796 mL	2.3593 mL	11.7963 mL
10 mM	0.1180 mL	0.5898 mL	1.1796 mL	5.8982 mL
20 mM	0.0590 mL	0.2949 mL	0.5898 mL	2.9491 mL
50 mM	0.0236 mL	0.1180 mL	0.2359 mL	1.1796 mL
100 mM	0.0118 mL	0.0590 mL	0.1180 mL	0.5898 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc