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Cyclo(RGDyK) trifluoroacetate

Name: Cyclo(RGDyK) trifluoroacetate
Brand: TargetMol
SKU: T6813
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6813Cas No. 250612-42-1

Alias Cyclo(RGDyK)

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Cyclo(RGDyK) trifluoroacetate

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Purity: 95.28%

Catalog No. T6813Alias Cyclo(RGDyK)Cas No. 250612-42-1

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$488	In Stock	In Stock
100 mg	$712	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:95.28%

Appearance:Solid

Color:White

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COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Targets&IC50	αvβ3 integrin:20 nM
In vitro	Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]
In vivo	In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]
Synonyms	Cyclo(RGDyK)

Chemical Properties

Molecular Weight	847.72
Formula	C₃₁H₄₃F₆N₉O₁₂
Cas No.	250612-42-1
Smiles	OC(C(F)(F)F)=O.NCCCC[C@@H]1NC([C@H](NC([C@@H](NC(CNC([C@@H](NC1=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC2=CC=C(C=C2)O)=O.OC(C(F)(F)F)=O
Relative Density.	no data available
Sequence	Arg-Gly-Asp-Tyr-Lys
Sequence Short	RGDYK

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (153.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1796 mL	5.8982 mL	11.7963 mL	58.9817 mL
5 mM	0.2359 mL	1.1796 mL	2.3593 mL	11.7963 mL
10 mM	0.1180 mL	0.5898 mL	1.1796 mL	5.8982 mL
20 mM	0.0590 mL	0.2949 mL	0.5898 mL	2.9491 mL
50 mM	0.0236 mL	0.1180 mL	0.2359 mL	1.1796 mL
100 mM	0.0118 mL	0.0590 mL	0.1180 mL	0.5898 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc