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HTS01037

Name: HTS01037
Brand: TargetMol
SKU: T15506
Rating: 4.5 (1 reviews)

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Catalog No. T15506Cas No. 682741-29-3

HTS01037 is a fatty acid-binding inhibitor and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).

HTS01037

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Catalog No. T15506Cas No. 682741-29-3

HTS01037 is a fatty acid-binding inhibitor and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$83	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	HTS01037 is a fatty acid-binding inhibitor and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki: 0.67 μM).
Targets&IC50	AFABP/aP2:0.67 μM
In vitro	HTS01037 inhibits lipolysis in 3T3-L1 adipocytes and decreases LPS-stimulated inflammation in cultured macrophages. HTS01037 functions as a high affinity ligand of AFABP/aP2 (apparent Ki: 0.67 μM). HTS01037 is somewhat selective for AFABP/aP2, but at higher concentrations is a pan-specific FABP inhibitor. Treatment of microglial cells with HTS01037 enhances expression of Ucp2 and arginase in the presence or absence of palmitic acid. HTS01037 acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophage or CV-1 cells[1]. Cells exposed to HTS01037 shows attenuated expression of inducible nitric oxide synthase (iNOS) compared to palmitic acid alone indicating reduced NFκB signaling[2]. Treatment of macrophages with HTS01037 causes a marked decrease in both basal and fatty acid-stimulated LTC4 secretion but no change in 5-HETE production or 5-lipoxygenase expression[3].

Chemical Properties

Molecular Weight	337.37
Formula	C₁₄H₁₁NO₅S₂
Cas No.	682741-29-3
Smiles	COC(=O)c1sc(cc1NC(=O)\C=C\C(O)=O)-c1cccs1
Relative Density.	1.493 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (444.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9641 mL	14.8205 mL	29.6410 mL	148.2052 mL
5 mM	0.5928 mL	2.9641 mL	5.9282 mL	29.6410 mL
10 mM	0.2964 mL	1.4821 mL	2.9641 mL	14.8205 mL
20 mM	0.1482 mL	0.7410 mL	1.4821 mL	7.4103 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	2.9641 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc