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DDP-38003 trihydrochloride

Name: DDP-38003 trihydrochloride
Brand: TargetMol
SKU: T10983
Rating: 4.5 (1 reviews)

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Catalog No. T10983

DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.

DDP-38003 trihydrochloride

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Catalog No. T10983

DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$1,570	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.
Targets&IC50	KDM1A/LSD1:84 nM
In vitro	DDP-38003 inhibits KDM1A with an IC50 of 84 nM. It is more effective in reducing colony-forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue [1].
In vivo	DDP-38003 demonstrates effectiveness in vivo upon oral administration, leading to a 62% increase in survival rates in mouse leukemia models via KDM1A inhibition. It has a half-life of 8 hours. A notable dose-dependent enhancement in survival rates of mice treated with DDP-38003 is observed, with survival rates escalating by 35% and 62% at doses of 11.25 and 22.50 mg/kg, respectively, showcasing its potential as a cancer therapeutic [1].

Chemical Properties

Molecular Weight	459.84
Formula	C₂₁H₂₉Cl₃N₄O
Smiles	O=C(NC1=CC=C([C@@H]2C[C@H]2N)C=C1)C(C=C3)=CC=C3N4CCN(C)CC4.Cl.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (217.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1747 mL	10.8733 mL	21.7467 mL	108.7335 mL
5 mM	0.4349 mL	2.1747 mL	4.3493 mL	21.7467 mL
10 mM	0.2175 mL	1.0873 mL	2.1747 mL	10.8733 mL
20 mM	0.1087 mL	0.5437 mL	1.0873 mL	5.4367 mL
50 mM	0.0435 mL	0.2175 mL	0.4349 mL	2.1747 mL
100 mM	0.0217 mL	0.1087 mL	0.2175 mL	1.0873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc