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WHI-P180

Name: WHI-P180
Brand: TargetMol
SKU: T2032
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2032Cas No. 211555-08-7

Alias Janex 3

WHI-P180 (Janex 3) is a potent inhibitor of EGFR and Cdk2, with IC50 values of 4.0 µM and 1.0 µM, respectively.

WHI-P180

🥰Excellent

Purity: 99.21%

Catalog No. T2032Alias Janex 3Cas No. 211555-08-7

WHI-P180 (Janex 3) is a potent inhibitor of EGFR and Cdk2, with IC50 values of 4.0 µM and 1.0 µM, respectively.

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$89	In Stock
10 mg	$135	In Stock
25 mg	$229	In Stock
50 mg	$342	In Stock
100 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Batch Information

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Purity:99.21%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	WHI-P180 (Janex 3) is a potent inhibitor of EGFR and Cdk2, with IC50 values of 4.0 µM and 1.0 µM, respectively.
Targets&IC50	CDK2:1.0 μM, KDR:66 nM, RET:5 nM, EGFR:4.0μM
Synonyms	Janex 3

Chemical Properties

Molecular Weight	297.31
Formula	C₁₆H₁₅N₃O₃
Cas No.	211555-08-7
Smiles	COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
Relative Density.	1.336 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (151.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3635 mL	16.8175 mL	33.6349 mL	168.1746 mL
5 mM	0.6727 mL	3.3635 mL	6.7270 mL	33.6349 mL
10 mM	0.3363 mL	1.6817 mL	3.3635 mL	16.8175 mL
20 mM	0.1682 mL	0.8409 mL	1.6817 mL	8.4087 mL
50 mM	0.0673 mL	0.3363 mL	0.6727 mL	3.3635 mL
100 mM	0.0336 mL	0.1682 mL	0.3363 mL	1.6817 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc