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Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2
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Catalog No. TMAB-11383
Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TNK1 (Tyr277). Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 can be used in WB.
Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2
Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-11383
Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TNK1 (Tyr277). Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-TNK1 (Tyr277). Anti-Phospho-TNK1 (Tyr277) Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Pig,Horse,Rabbit,GuineaPig) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Membrane; Peripheral membrane protein. |
| Tissue Specificity | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human TNK1 around the phosphorylation site of Tyr277 |
| Antigen Species | Human |
| Gene Name | TNK1 |
| Gene ID | |
| Protein Name | Non-receptor tyrosine-protein kinase TNK1 |
| Uniprot ID | |
| Function | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Molecular Weight | Theoretical: 73 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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